Science-based information about the melanocortin-4 receptor pathway
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Congresses and meetings relevant to rare melanocortin-4 receptor pathway diseases throughout 2023
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Welcome to path4HCPs
Here you can learn more about rare melanocortin-4 receptor (MC4R) pathway diseases, their diagnosis and management.
Rare MC4R pathway diseases can be caused by genetic variants within the pathway (part of the central melanocortin pathway). These changes can impair signalling in the pathway that controls hunger and can be a root cause of increased appetite and body weight.1
To accurately diagnose and care for those possibly living with a rare MC4R pathway disease, it is crucial to undertake a detailed observation of the patient and gain confirmation of any underlying genetic cause.
A proper understanding of a root cause of the disease allows for appropriate management and care of patients.1
Here you can find information about rare MC4R pathway diseases, including:
How to identify genetic causes of obesity and related syndromes. Understanding the role of the MC4R pathway in monogenic obesity and Bardet-Biedl syndrome
- Yazdi F et al, Peerj, 2023;3;e856
- Huvenne H, et al. Obes Facts. 2016;9(3):158-173
- Forsythe et al., Orphanet Journal. 2023; 18(12)